Best Dog Urine Enzyme Cleaner in 2022 [*Top Picks*]

Looking for the best dog urine enzyme cleaner on the market? We’ve got you covered. Check out our ratings of absolute bestsellers below and make a final decision.

6061 Reviews Scanned

  • Rocco & Roxie Stain & Odor Eliminator for Strong Odor - Enzyme-Powered Pet Odor Eliminator for Home - Carpet Stain Remover for Cats and Dog Pee - Enzymatic Cat Urine Destroyer - Carpet Cleaner Spray
    Bestseller #1
    Rocco & Roxie Stain & Odor Eliminator for Strong Odor - Enzyme-Powered Pet Odor Eliminator for Home - Carpet Stain Remover for Cats and Dog Pee - Enzymatic Cat Urine Destroyer - Carpet Cleaner Spray (3003)
      CERTIFIED GENTLE AND SAFE Chlorine free and color safe. Safe to use around pets and children. No hazardous propellants, no residue left behind. So gentle it’s been Certified Safe for all carpets, earning the Seal of Approval by the trusted Carpet and Rug Institute (CRI) ELIMINATES STAINS, ODORS AND RESIDUE If it’s gross, it’s gone. Not just the stain, but the stink. From stinky yellow pet urine and feces to vomit and other organic spills, our professional strength formula tackles them all. EVERY SURFACE, EVERY TIME For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areas—anywhere stains happen. ENZYME ACTIVATED The key is getting to the problem deep-down. This spray contains natural enzymes that are activated on contact with odors and stains, feeding on ammonia crystals and organic matter until they are completely eliminated. 100% SATISFACTION GUARANTEED An Amazon best seller—for a reason. If your stains and odors aren’t gone, neither is your money. We’ll refund it in full.
  • Simple Solution Pet Stain and Odor Remover | Enzymatic Cleaner with 2X Pro-Bacteria Cleaning Power | 32 Ounces
    Bestseller #1
    Simple Solution Pet Stain and Odor Remover | Enzymatic Cleaner with 2X Pro-Bacteria Cleaning Power | 32 Ounces (386)
      REMOVES PET STAINS- Simple Solution Stain & Odor Remover is formulated to eliminate and neutralize tough dog and cat stains and odors like urine, feces, and vomit UNIQUE PRO-BACTERIA FORMULA - This stain and odor remover has a unique Pro-Bacteria and enzyme formula that eliminates stains and odors, and helps prevent repeat marking MULTIPLE USES - Safely removes dog and cat stains and odors from carpet, upholstery, bedding, fabric toys, clothing, and other water-safe surfaces in your home VERSATILE CLEANING - Our patented 3-in-1 nozzle sprayer gives you more options to tackle stains and odor: stream, foam, or mist
  • Angry Orange Enzyme Cleaner & Pet Stain Remover Spray - 32oz Pet Odor Eliminator for Home, Carpet, and Floor - Cat and Dog Urine Destroyer (Fresh Citrus Scent) 
    Bestseller #1
    Angry Orange Enzyme Cleaner & Pet Stain Remover Spray - 32oz Pet Odor Eliminator for Home, Carpet, and Floor - Cat and Dog Urine Destroyer (Fresh Citrus Scent)  (12898)
      Enjoy all the furry love without the nasty messes! Our enzyme-active pet stain and odor remover can tackle any stubborn stains and foul smells, including pet urine, feces, and even vomit. This isn't just another pet spray that masks the bad odors and stains. Our floor & carpet odor eliminator destroys them with enzymes that activate upon contact and ensure 80 hours of freshness. Discover an enzyme cleaner that can clean it all! Our solution is a pet cleaner for carpet, hardwood floors, tile, litter boxes, pillows, kennels, and more. Made with enzymes and natural ingredients, this odor & urine remover for dogs and cats will leave a subtle orange scent behind without the use of harsh ingredients. We care about making a great enzymatic cleaner with the strength to destroy messes, and keeping you and your pets happy. If you have any questions or concerns, our customer support is available 24/7.
  • Simple Green Bio Dog Active Stain & Odor Remover - Enzyme Cleaner & Stain Remover for Carpet, Rugs & Fabric – eliminates Urine Odor (32 oz Spray & 1 gal Refill)
    Bestseller #1
    Simple Green Bio Dog Active Stain & Odor Remover - Enzyme Cleaner & Stain Remover for Carpet, Rugs & Fabric – eliminates Urine Odor (32 oz Spray & 1 gal Refill) (386)
      Permanently eliminates tough stains and unpleasant odors from urine, feces, vomit, scent markings, dirt, blood and more Use on porous surfaces such as carpet, rugs, pet bedding, fabric, upholstery, clothing, curtains, Auto upholstery, crates, tile, finished wood, laminates, concrete and more Uses powerful, natural enzymes to eliminate odors at the source rather than cover them up Safe for use around pets Eliminates new, old and set-in stains
  • Simple Solution Cat Extreme Pet Stain and Odor Remover | Enzymatic Cleaner with 3X Pro-Bacteria Cleaning Power | 32 Ounces
    Bestseller #1
    Simple Solution Cat Extreme Pet Stain and Odor Remover | Enzymatic Cleaner with 3X Pro-Bacteria Cleaning Power | 32 Ounces (386)
      DESIGNED FOR THE TOUGHEST ODORS AND ORGANIC STAINS- Simple Solution pet Extreme Stain and Odor remover is three times stonger than our regular formula to eliminate tough dog and cat odors and stains. PROFESSIONAL STRENGTH FORMULA - Extreme Stain and Odor Remover is a professional strength Pro-Bacteria and enzyme formula that breaks down and eliminates stains and odors. SPECIFICALLY FOR PET ODORS AND ORGANIC STAINS - Safely and quickly removes dog and cat urine, feces, and vomit on carpet, upholstery, bedding, fabric toys, clothing, or other water-safe surfaces in your home NEW PATENTED MULTI-FUNCTIONAL SPRAYER - Now designed with a new patented 3-in-1 nozle sprayer (foam, mist, and stream).
  • OUT! PetCare Advanced Stain and Odor Remover | Pro-Bacteria and Enzyme Formula for Tough Stains and Odor | 32 oz (Pack of 2)
    Bestseller #1
    OUT! PetCare Advanced Stain and Odor Remover | Pro-Bacteria and Enzyme Formula for Tough Stains and Odor | 32 oz (Pack of 2) (386)
      TACKLE TOUGH STAINS: 3x Pro-Bacteria and Enzyme formula cleans deep to remove the severe stains in your home. PATENTED 3-IN-1 SPRAYER: This multifunctioning sprayer allows you to tackle any kind of stain that comes your way, and elimintae it the first time. ELIMINATE EVERYDAY MESSES: Formula fights more than just pet stains, and is effective in cleaning and eliminating your everyday spills around the house. CERTIFIED CLEANER: Certified by the Carpet and Rug Institute, you can clean your carpets, bedding and most water-safe surfaces with confidence. REMOVE UNWANTED ODORS: The Enzyme formula destroys the odor-causing bacteria to eliminate those unwanted smells.
  • BUBBAS Super Strength Commercial Enzyme Cleaner - Pet Odor Eliminator | Enzymatic Stain Remover | Remove Dog Cat Urine Smell from Carpet, Rug or Hardwood Floor and Other Surfaces (Gallon)
    Bestseller #1
    BUBBAS Super Strength Commercial Enzyme Cleaner - Pet Odor Eliminator | Enzymatic Stain Remover | Remove Dog Cat Urine Smell from Carpet, Rug or Hardwood Floor and Other Surfaces (Gallon) (243)
      BEST PROFESSIONAL GRADE CLEANING SOLUTION: Scientifically formulated to be more potent than other pet odor enzyme cleaners for your flooring, upholstery, area rugs and carpets, yet safe to use around kids and pets. Permanently destroys pet enzyme odors and stains PET STAIN AND ODOR MIRACLE: Bubba's uses natural dormant enzymes that become active upon hitting that strong smelling cat pee, billions of enzymes destroy stains down to the carpet pad. Competitors use active enzymes that die off and lose effect SATISFACTION GUARANTEED: Other pet odor enzyme sprays use active enzymes that are ineffective soon after you buy them. Bubba's dormant enzyme formula is the best premium deep cleaning stain and pet urine enzyme carpet cleaner or YOUR MONEY BACK CARPET & RUG INSTITUTE CERTIFIED: Our Pet Pee Cleaner and Enzymatic Odor Remover is a Top Rated pet stain & odor miracle. Don't be disappointed by other brands pet cleaner sprays. Try Bubbas pet enzyme treatment cleaner instead MANY USES: Our enzyme based stain remover and cleaning solution can be used in all areas of your house, auto, kitchen, bathroom, laundry room and more. Use to remove shoe odor, clean auto carpeting stains, use as clothes pretreat for removal of tough set in grass stains. litter box cleaner, or on furniture to remove odors
  • Eco Strong Outdoor Odor Eliminator | Outside Dog Urine Enzyme Cleaner – Powerful Pet, Cat, Animal Scent Deodorizer | Professional Strength for Yard, Turf, Kennels, Patios, Decks (Gallon with Sprayer)
    Bestseller #1
    Eco Strong Outdoor Odor Eliminator | Outside Dog Urine Enzyme Cleaner – Powerful Pet, Cat, Animal Scent Deodorizer | Professional Strength for Yard, Turf, Kennels, Patios, Decks (Gallon with Sprayer) (120)
      Powerful All-Natural Odor Eraser: Our Chemical-free formula is a Pet Poop & Pee Smell destroyer. Not even skunk spray can stand up to Eco Strong’s bioactive potency. Spray it on any outdoor surface, and odors will quickly and permanently disappear. Paw & Barefoot Safe: Our professional strength bio-enzymatic solution erases offensive odors without leaving behind irritating and inflammatory residue. This product does not contain any harmful enzymes. Multi-Purpose: No job is too big or small for this solution; whether you have an apartment patio with no yard hose access (use Eco Strong Outdoor Odor Eliminator Spot Treat) or a large yard, we have you covered. Long-Lasting: Thanks to our super-concentrated formulation, one treatment, when used as directed, can last several weeks. Satisfaction Guaranteed: We guarantee the effectiveness of our Outdoor Odor Eliminator with a 100% money-back guarantee. We don’t mask foul animal organic odors; we destroy them at the source with powerful bioactive efficiency. Try it risk-free and experience the Eco Strong difference today.
  • Simple Solution Pet Urine Destroyer | Enzymatic Cleaner with 2X Pro-Bacteria Cleaning Power | Targets Urine Stains and Odors | 1 Gallon
    Bestseller #1
    Simple Solution Pet Urine Destroyer | Enzymatic Cleaner with 2X Pro-Bacteria Cleaning Power | Targets Urine Stains and Odors | 1 Gallon (386)
      TOUGH ON URINE - Simple Solution Pet Urine Destroyer combines Pro-Bacteria and Enzymes in a formula that neutralizes the toughest urine odors and discourages future marking. ELIMINATE STAINS – Simple Solution’s enzymatic cleaner technology lifts urine stains leaving your carpet stain and odor free. MULTIPLE USES – Our pet odor and stain remover is safe to use on carpet, upholstery, bedding, fabric toys, clothing and other water-safe surfaces in your home when used as directed. CARPET SAFE – Certified by the Carpet and Rug Institute, our Pet Urine Destroyer is safe to use on all colorfast carpets when used as directed. SAFE FOR THE HOME – Simple Solution pet urine remover is safe for use around pets and your household when used as directed.
  • Simple Solution Pet Stain and Odor Remover | Enzymatic Cleaner with 2X Pro-Bacteria Cleaning Power | Floral Fresh, 32 Ounces
    Bestseller #1
    Simple Solution Pet Stain and Odor Remover | Enzymatic Cleaner with 2X Pro-Bacteria Cleaning Power | Floral Fresh, 32 Ounces (386)
      removes pet stains - simple solution floral fresh pet stain & odor remover eliminates and neutralizes tough pet stains and odors such as urine, feces, or vomit, leaving behind a pleasant floral scent. unique pro-bacteria formula - our stain and odor remover has a unique formula that uses 2x pro-bacteria and enzymes to eliminate pet stains and odors, and help prevent repeat marking by pets. breathe deep and relax - leave your home smelling spring fresh with our pleasing floral scent. new patented multi-functional sprayer - designed with a 3-in-1 nozzle sprayer: foam, mist, and stream. bottle comes with a seal cap and detached sprayer to prevent leaks in transit. made in the usa. works on water safe surfaces - safely removes pet stains and odors on carpet, upholstery, bedding, fabric toys, clothing, or other water-safe surfaces in your home. Age range description: All Stages
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